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09:03
Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
Published on: November 7, 2020
Three men, a paint brush and a coronavirus.
A A Macconnachie1, T C Collins, R A Seaton
1Brownlee Centre, Gartnavel General Hospital, 1053 Great Western Road, Glasgow, G12 0YN, UK. allymac@doctors.org.uk
International Journal of STD & AIDS
|March 3, 2007
Summary
This study highlights coronavirus respiratory infections in HIV patients, often worsening chronic obstructive pulmonary disease. These infections necessitate extensive medical care, underscoring the need for consideration in immunocompromised individuals.
Area of Science:
- Virology
- Infectious Diseases
- Immunocompromised Host Research
Background:
- Coronaviruses typically cause upper respiratory tract infections.
- Gastroenteritis is a known manifestation in Human Immunodeficiency Virus (HIV) patients.
- Limited data exists on respiratory infections caused by coronaviruses in HIV patients, barring Severe Acute Respiratory Syndrome (SARS).
Observation:
- Two HIV-positive patients experienced exacerbations of chronic obstructive pulmonary disease (COPD) with confirmed coronavirus infection.
- A third HIV-positive patient presented with an upper respiratory tract infection, though coronavirus was not isolated.
- All three individuals shared a common exposure event four days before symptom onset.
Findings:
- This case series represents the first documented instances of respiratory tract infection with coronavirus in patients with HIV.
- Coronavirus infections in these HIV patients led to prolonged hospitalizations and intensive diagnostic workups.
- The severity of illness in these cases suggests coronaviruses can cause significant respiratory disease in immunocompromised individuals.
Implications:
- Coronavirus should be considered in the differential diagnosis of respiratory tract infections in patients with HIV.
- The findings emphasize the potential for coronaviruses to cause severe respiratory illness in immunocompromised populations.
- Further research is warranted to understand the spectrum and management of coronavirus infections in HIV patients.
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