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Updated: Jul 16, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
[Determination of the fluorine release of fluoride varnishes by neutron activation method]
Ya-kun Ping1, Hong-ying Liu, Dong-mei Liu
1Department of Pediatric Dentistry, School of Stomatology, Hebei Medical University, Shijiazhuang 050017, China. pingyakun64@sina.com
Objective:
To determine the fluorine content in enamel before and after besmearing fluoride varnishes by neutron activation method.
Methods:
A pair of mandibular deciduous central incisor teeth were chosen. One was removed, and the other was besmeared with fluoride varnishes and removed 24 hours later. The contents of fluorine were determined and analyzed statistically.
Results:
The fluorine content in the enamel of the tooth besmeared with fluoride varnishes was higher than that in the control tooth (P < 0.05).
Conclusions:
The application of the fluoride varnishes can effectively increase the content of fluorine in the sclerous tissues.
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