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[A clinical analysis of early stage infection after auto peripheral blood stem cell transplantation]
Ming-hui Duan1, Dao-bin Zhou, Shu-jie Wang
1Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. mhduan@sina.com
Objective:
To analyze the incidence, risk factors, treatment and prognosis of early stage infection after auto peripheral blood stem cell transplantation (APBSCT).
Methods:
The clinical data of 120 patients receiving APBSCT were analyzed.
Results:
The incidence rate of infection was 57.5% (69/120), with most of them (68/69) bacterial in origin. 2.5% (3/120) the patients died of infection. The first infection was usually observed on the 6th day after APBSCT and lasted for a median of 2 (1 - 23) days. Positive blood culture was found in 16.0% (11/69) of the patients, with all of them G(-) bacteria. Patients with age more than 45 years and not receiving CD(34)(+) sorting had higher infection rate. 61.8% (42/68) of the patients responded to treatment for the first infection within 48 hours.
Conclusions:
The early stage infection rate after APBSCT is 57.5%, with most of them bacterial in origin. Most of the infections respond to broad-spectrum antibiotics. Patients with age more than 45 years and not receiving CD(34)(+) sorting have higher infection rate.
