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Related Experiment Videos

Selection bias in in vitro fertilization programs.

A Hershlag1, E H Kaplan, R A Loy

  • 1Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.

American Journal of Obstetrics and Gynecology
|January 1, 1992
PubMed
Summary
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Pregnancy rates in in vitro fertilization-embryo transfer (IVF-ET) programs differ significantly. Selection biases during patient entry and between treatment cycles may explain these variations in IVF success rates.

Area of Science:

  • Reproductive medicine
  • Infertility treatments
  • Clinical trial analysis

Background:

  • Reported pregnancy rates per cycle from various in vitro fertilization-embryo transfer (IVF-ET) programs exhibit considerable variation.
  • Some IVF-ET programs consistently report stable pregnancy rates, while others indicate a downward trend.

Purpose of the Study:

  • To investigate the reasons behind the wide discrepancies in reported pregnancy rates per cycle among different IVF-ET programs.
  • To explore the potential impact of selection biases on the observed variations in IVF-ET success rates.

Main Methods:

  • Analysis of reported pregnancy rates across multiple IVF-ET programs.
  • Discussion of potential selection biases at program entry.
  • Examination of selection biases occurring between treatment cycles.

Related Experiment Videos

Main Results:

  • Significant variability exists in reported pregnancy rates per cycle across different IVF-ET programs.
  • Observed discrepancies in success rates are potentially attributable to selection biases.

Conclusions:

  • Selection biases are a critical factor that may explain the wide range of reported pregnancy rates in IVF-ET.
  • Further investigation into patient selection criteria and cycle progression is warranted to understand variations in IVF-ET outcomes.