Alloimmune thrombocytopenia may be associated with systemic disease

Adverse outcome was encountered in a case of neonatal alloimmune thrombocytopenia after in utero platelet transfusion. This may have resulted from generalized systemic vascular endothelial damage, because several cell types, including umbilical endothelial cells, have been shown to contain surface molecules similar to the receptor containing the PlA1 antigen.