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Rapid growth of leiomyoma in patient receiving tamoxifen

P V Dilts1, M P Hopkins, A E Chang

  • 1Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor 48109-0718.

American Journal of Obstetrics and Gynecology
|January 11, 1992
PubMed

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...