Related Experiment Video
Updated: Jul 16, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Antibacterial properties of self-etching dental adhesive systems
Osnat Feuerstein1, Shlomo Matalon, Hagay Slutzky
1Department of Prosthodontics, Faculty of Dental Medicine, Hebrew University, Jerusalem, Israel.
Background:
Dental adhesives with antibacterial properties may reduce recurrent or secondary caries. The authors conducted a study to examine the immediate and long-lasting antibacterial properties of four self-etching adhesive systems.
Methods:
The authors used the agar diffusion test (ADT) and direct contact test (DCT) to measure the antibacterial properties of AdheSe (Ivoclar Vivadent, Schaan, Liechtenstein), Adper Prompt L-Pop (3M ESPE, Seefeld, Germany), Clearfil Protect Bond (Kuraray, Kurashiki, Okayama, Japan) and Xeno III (Dentsply, Konstanz, Germany) on Streptoccocus mutans after aging samples in phosphate-buffered saline for one, two, seven and 14 days.
Results:
Only Clearfil Protect Bond showed an inhibition halo in the ADT. In the DCT, fresh samples of all of the tested materials exhibited potent antibacterial properties, which were maintained by AdheSe for one day and Clearfil Protect Bond for seven days. None of the adhesive systems exhibited any antibacterial properties after 14 days.
Conclusions:
All of the tested adhesives had an immediate bactericidal effect on S. mutans. None, however, had long-lasting antibacterial properties.
Clinical Implications:
The application of self-etching adhesive materials could contribute to the immediate elimination of residual bacteria. The likelihood of developing secondary caries as a consequence of bacterial microleakage may not be affected by the use of the adhesive systems tested in this study.
Related Concept Videos
Antimicrobial Effectiveness
EDTA: Chemistry and Properties
Hand hygiene
Hand washing...
Waterproofing and Anti-Bacterial Admixtures in Concrete
Waterproofing admixtures render concrete hydrophobic,...
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Bacterial Signaling

