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Updated: Jul 16, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
How diagnosis-related group 559 will change the US Medicare cost reimbursement ratio for stroke centers
Bart M Demaerschalk1, Donna L Durocher
1Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA. Demaerschalk.Bart@mayo.edu
Insights
Acute ischemic stroke thrombolysis is cost-effective for society but costly for hospitals. The new Diagnosis-Related Group 559 significantly improves hospital reimbursement, making acute stroke care more economically viable.
Area of Science:
- Health Economics
- Neurology
- Healthcare Management
Background:
- Thrombolysis for acute ischemic stroke offers societal cost savings.
- Hospitals providing acute stroke care face financial challenges due to costs exceeding reimbursement.
- The introduction of Diagnosis-Related Group (DRG) 559 by Medicare aimed to address this imbalance.
Purpose of the Study:
- To determine the total cost and reimbursement for acute stroke treatment with thrombolysis.
- To analyze the economic impact of DRG 559 on hospital finances for acute stroke care.
Main Methods:
- Data collected from September 2001 to December 2004 for patients receiving thrombolysis for acute stroke.
- Calculated hospital costs and reimbursement per patient.
- Analyzed financial data using a cost-reimbursement ratio, both before and after the implementation of DRG 559.
Main Results:
- Sixty-seven patients were analyzed (mean age 72, mean length of stay 4.4 days).
- The cost-reimbursement ratio was 1.41 before DRG 559.
- The estimated cost-reimbursement ratio after DRG 559 was 0.82, indicating improved financial viability.
Conclusions:
- Hospital costs for acute ischemic stroke thrombolysis historically exceeded Medicare reimbursement.
- The implementation of DRG 559 is projected to establish a favorable cost-reimbursement ratio for hospitals.
- DRG 559 is expected to improve the economic sustainability of acute stroke care centers.
Background And Purpose:
Thrombolysis for acute ischemic stroke saves societal costs, but hospitals that practice acute stroke care appear to shoulder the burden of the cost, which exceeds reimbursement. With creation of the diagnosis-related group (DRG) 559, the US Centers for Medicare and Medicaid Services pays hospitals approximately US $6000 more per case when thrombolysis is administered. We sought to determine the total cost of, and reimbursement for, acute stroke treatment with thrombolysis at a single stroke center and the economic impact of DRG 559.
Methods:
Between September 2001 and December 2004, we collected data on all patients with acute stroke who received thrombolysis. We identified all hospital costs and reimbursement per patient. Financial results were expressed as a cost-reimbursement ratio: average total cost to average total reimbursement per patient. We then reanalyzed data using the projected Medicare hospital reimbursement with DRG 559.
Results:
Sixty-seven patients with stroke (mean age, 72 years) were treated (mean length of stay, 4.4 days; mean stroke severity, National Institutes of Health Stroke Scale score of 15; and symptomatic intracranial hemorrhage rate, 7%). The cost-reimbursement ratio was 1.41 (95% CI=0.98 to 2.28) before DRG 559 and estimated to be 0.82 (95% CI=0.66 to 0.97) after DRG 559.
Conclusions:
Our hospital costs have traditionally exceeded Medicare reimbursement for the acute care of thrombolyzed patients with ischemic stroke, but with DRG 559, a new economically favorable cost-reimbursement ratio for hospitals will be established.
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