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Increased glucose transport in nonexercising muscle
L A Megeney1, G C Elder, M H Tan
1Department of Kinesiology, University of Waterloo, Ontario, Canada.
The American Journal of Physiology
|January 1, 1992
Summary
Exercise and insulin increase glucose transport in nonexercising muscles. This study investigated 3-O-methyl-D-glucose transport in rat hindlimb muscles under various conditions, revealing significant increases with both stimuli.
Area of Science:
- Physiology
- Exercise Science
- Metabolism
Background:
- Muscle glucose uptake is crucial for energy homeostasis.
- Exercise and insulin are known stimulators of glucose transport.
- The impact on nonexercising muscles during exercise warrants further investigation.
Purpose of the Study:
- To compare 3-O-methyl-D-glucose (3-MG) transport in exercised and nonexercised rat hindlimb muscles.
- To determine the effects of exercise and insulin on glucose transport in different muscle types.
- To investigate the combined effects of exercise and insulin on glucose uptake.
Main Methods:
- Perfused rat hindlimb muscles (soleus, plantaris, gastrocnemius) were used.
- Four treatment groups: normal rest, normal exercise, hindlimb-suspended rest, and hindlimb-suspended exercise.
- 3-O-methyl-D-glucose (3-MG) transport was measured in the absence and presence of insulin (30 nM).
Main Results:
- Muscle activity was reduced in hindlimb-suspended muscles during rest and exercise.
- Glycogen decreased in nonexercising muscles during exercise.
- Both exercise and insulin independently increased 3-MG transport, with an additive effect observed.
- 3-MG transport increased in nonexercised muscles, even without insulin, and further increased in the presence of insulin.
Conclusions:
- Exercise and insulin stimulate glucose transport in nonexercising muscles.
- Glucose transport capacity varies among different hindlimb muscles.
- The findings suggest a systemic increase in glucose uptake during exercise, involving nonexercising muscle groups.