Related Experiment Video
Updated: Jul 16, 2026

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
Published on: August 20, 2019
Are the endothelial mechanisms of ACE-Is already established?
Włodzimierz Buczko1, Karol Kramkowski, Andrzej Mogielnicki
1Department of Pharmacodynamics, Medical University of Białystok, Mickiewicza 2C, PL 15-089 Białystok, Poland. pharmdyn@amb.edu.pl
Abstract:
The endothelial mechanism of ACE-Is action is multifaceted. On the one hand, by inhibiting ACE, ACE-Is diminish Ang II synthesis, one of the best known active peptides. On the other hand, they modify synthesis and release of PGI(2) and NO via increasing production of other biologically important peptides like bradykinin, Ang-(1-7) or Ang-(1-9). Thus, ACE-Is play a crucial role in the function of endothelium and are effective and important tool for therapy of range of cardiovascular system disorders. Moreover, they are sensitive pharmacological instrument to elucidate and expand our knowledge about the role of RAS in human patophysiology.
More Related Videos
Related Concept Videos
Cholesterol: Significance and Regulation
Considering cholesterol and...
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Mechanism of Angiogenesis
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids

