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Plasmalogens in human serum positively correlate with high- density lipoprotein and decrease with aging

Ryouta Maeba1, Tomomi Maeda, Makoto Kinoshita

  • 1Department of Biochemistry, Teikyo University School of Medicine, Tokyo, Japan. maeba@med.teikyo-u.ac.jp

Journal of Atherosclerosis and Thrombosis
|March 3, 2007
PubMed

Insights

Serum plasmalogens, antioxidant phospholipids, are beneficial factors in human plasma, positively correlating with HDL and decreasing with age. Their measurement is useful for clinical diagnosis.

Area of Science:

  • Biochemistry
  • Cardiovascular Research
  • Gerontology

Background:

  • Plasmalogens are ether phospholipids with antioxidant properties.
  • Aging is associated with decreased plasmalogen levels.
  • Plasmalogens may play a role in cardiovascular health.

Purpose of the Study:

  • To investigate the association of serum plasmalogens with cardiovascular risk factors.
  • To determine the impact of aging on serum plasmalogen levels.
  • To propose plasmalogens as a beneficial plasma factor.

Main Methods:

  • Analysis of serum plasmalogens and biochemical markers in elderly subjects with suspected coronary artery disease (CAD).
  • Clinical evaluation of coronary stenosis, hyperlipidemia, abnormal glucose tolerance, and hypertension.
  • Comparison of plasmalogen levels between elderly and young healthy subjects.

Main Results:

  • Serum plasmalogen levels decreased with aging and were lower in subjects with coronary stenosis and abnormal glucose tolerance.
  • Plasmalogens showed a positive correlation with high-density lipoprotein (HDL) and apolipoprotein A-I (apo A-I).
  • The ratio of choline plasmalogen (ChoPlas) to ethanolamine plasmalogen (EtnPlas) correlated with low-density lipoprotein (LDL) particle size and negatively with apo A-II and triglycerides (TG).

Conclusions:

  • Serum plasmalogens function as beneficial factors in human plasma, similar to HDL.
  • Reduced plasmalogen levels are linked to aging and cardiovascular risk factors.
  • Serum plasmalogen measurement is a potentially useful tool for clinical diagnosis.
Abstract

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