Related Experiment Video
Updated: Jul 16, 2026
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
Durable response of a radiation-induced, high-grade cerebellar glioma to temozolomide
Michelle L Monje1, Naren R Ramakrishna, Geoffrey Young
1Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Background:
Radiation-induced high-grade gliomas are a rare but serious late complication of radiotherapy. We report a patient with radiation-induced cerebellar high-grade glioma who had a durable response to temozolomide.
Patients And Methods:
Case report of a 77-year-old woman with a radiation-induced, high-grade cerebellar glioma that responded durably to temozolomide.
Results:
Our patient developed a cerebellar high-grade glioma 9 years after treatment for a stage IV (T4N0M0) supraglottic laryngeal squamous cell carcinoma with cisplatinum and fluorouracil chemotherapy, and subsequently focal head and neck radiotherapy. Patient was treated with radiation and concurrent temozolomide (only partially due to toxicity) and was stable for 1 year without further adjuvant treatment. Subsequently the tumor recurred and the patient had a dramatic and durable response to standard 5 day dosing of adjuvant temozolomide.
Conclusion:
High-grade gliomas are a late complication of radiation to the central nervous system and may respond to chemotherapy.
Related Concept Videos
02:56Treatment Resistent Cancers
02:56Treatment Resistant Cancers