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Related Concept Videos

Reabsorption and Secretion in the Loop of Henle01:17

Reabsorption and Secretion in the Loop of Henle

The thick ascending limb of the nephron loop has Na+–K+–2Cl− symporters in the apical membranes of its cells. These symporters simultaneously reclaim one sodium ion, one potassium ion, and two chloride ions from the tubular fluid. Sodium ions are actively transported into the interstitial fluid at the base and sides of the cell, diffusing into the vasa recta. Chloride ions move through leakage channels in the basolateral membrane into the interstitial fluid and then into the vasa recta.
Primary Active Transport01:29

Primary Active Transport

In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would not...
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The kidneys maintain homeostasis through filtration, reabsorption, and secretion. Tubular reabsorption and secretion are crucial in forming urine and regulating electrolytes, water balance, and waste elimination.Tubular Reabsorption and Secretion ProcessesTubular reabsorption is the process that reclaims essential substances such as electrolytes, glucose, amino acids, and water from the glomerular filtrate back into the bloodstream. This is achieved through passive and active transport...
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Related Experiment Video

Updated: Jul 16, 2026

Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays
12:48

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Published on: February 19, 2013

Potassium transport in the maturing kidney.

Sevgi Gurkan1, Genevieve K Estilo, Yuan Wei

  • 1Department of Pediatrics, Division of Nephrology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1664, New York, NY, 10029, USA.

Pediatric Nephrology (Berlin, Germany)
|March 3, 2007
PubMed
Summary

The neonatal kidney retains potassium (K+) due to fewer secretory channels and more absorptive H-K-adenosine triphosphatase (ATPase). Understanding these K+ transport mechanisms is key for treating imbalances.

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Area of Science:

  • Nephrology
  • Physiology
  • Pediatrics

Background:

  • The distal nephron and colon regulate potassium (K+) homeostasis.
  • Adult kidneys primarily secrete K+, while neonatal kidneys retain K+.

Purpose of the Study:

  • To review recent advances in K+ transport mechanisms in the maturing kidney.
  • To understand K+ balance regulation in infants and children.

Main Methods:

  • Review of existing literature on K+ transport.
  • Analysis of factors influencing K+ secretion and absorption.

Main Results:

  • Neonatal kidneys exhibit K+ retention due to absent apical secretory K+ channels and predominant apical H-K-adenosine triphosphatase (ATPase).
  • Both luminal and peritubular factors regulate the balance between K+ secretion and absorption.

Conclusions:

  • Understanding K+ transport mechanisms in the maturing kidney is crucial.
  • Factors regulating K+ balance are potential targets for treating hyper- and hypokalemia.