Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New metabolic lung simulator: development, description, and validation.

Abraham Rosenbaum1, Christopher Kirby, Peter H Breen

  • 1Department of Anesthesiology UCI Medical Center, University of California, Irvine, Building 53, Room 227, 101 The City Drive South, Orange, CA 92868, USA.

Journal of Clinical Monitoring and Computing
|March 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice.

eLife·2025
Same author

Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice.

bioRxiv : the preprint server for biology·2024
Same author

Adaptive tail-length evolution in deer mice is associated with differential Hoxd13 expression in early development.

Nature ecology & evolution·2024
Same author

Paediatric Gastrointestinal, Hepatic and Pancreatic Inflammatory Myofibroblastic Tumours, A Single Centre Experience.

Journal of pediatric gastroenterology and nutrition·2021
Same author

The Tug1 lncRNA locus is essential for male fertility.

Genome biology·2020
Same author

Dextran sulfate sodium mouse model of inflammatory bowel disease evaluated for systemic genotoxicity via blood micronucleus and Pig-a gene mutation assays.

Mutagenesis·2020
Same journal

Alert burden when monitoring patients' vital signs continuously at home.

Journal of clinical monitoring and computing·2026
Same journal

Not all anesthetic techniques fit the questions: editorial fit reflects scientific fit.

Journal of clinical monitoring and computing·2026
Same journal

Correction: Clinical validation of an adapted Eleveld Model for high‑dose propofol treatments for depression.

Journal of clinical monitoring and computing·2026
Same journal

Safety and efficacy of distal versus conventional radial artery cannulation for invasive blood pressure monitoring: a systematic review and meta-analysis.

Journal of clinical monitoring and computing·2026
Same journal

Data availability and usability of a remote device for vital sign monitoring on general wards and home: a single-center prospective, observational study.

Journal of clinical monitoring and computing·2026
Same journal

Nociception-guided opioid administration within multimodal analgesia for laparoscopic endometriosis surgery: a randomized controlled trial.

Journal of clinical monitoring and computing·2026
See all related articles

A novel metabolic lung simulator accurately generates reference values for carbon dioxide elimination (VCO2) and oxygen uptake (VO2). This system aids in validating indirect calorimetry instruments for improved patient monitoring.

Area of Science:

  • Biomedical Engineering
  • Physiology
  • Respiratory Medicine

Background:

  • Indirect calorimetry measures airway carbon dioxide elimination (VCO2) and oxygen uptake (VO2) to assess tissue metabolism.
  • Validating indirect calorimetry instruments is challenging due to the lack of a reference standard and difficulty achieving steady-state conditions in patients.

Purpose of the Study:

  • To develop and validate a practical metabolic lung simulator for generating accurate, adjustable, and stable reference values of VCO2 and VO2.
  • To provide a reliable tool for the calibration and validation of indirect calorimetry methodology and clinical monitoring devices.

Main Methods:

  • A metered alcohol combustion system precisely delivered ethanol to generate reference VCO2 and VO2.
  • A circular circuit with a mechanical lung simulated mammalian gas kinetics, including ventilation waveforms and non-steady-state conditions.

Related Experiment Videos

  • Reference gas generation was validated against independent measurements of gas flow and fractions.

    • Main Results:

    • The system demonstrated high accuracy, with average errors for VCO2 and VO2 within +/- 4.86% across different ventilation modes.
    • Complete and pure combustion was confirmed by low levels of ethanol vapor and carbon monoxide.
    • The simulator successfully generated a wide range of stable reference values for VCO2 and VO2.

    Conclusions:

    • The developed metabolic lung simulator offers a robust solution for calibrating and validating indirect calorimetry.
    • This technology can significantly improve the accuracy of patient monitoring in critical care and anesthesia.
    • The study provides a foundation for future research in metabolic gas exchange analysis.