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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Disorders of Erythrocytes01:27

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Related Experiment Video

Updated: Jul 16, 2026

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
05:35

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

Elevated red cell volume in North Indian students.

D Mohanty1, N Kakkar, J Cherian

  • 1Institute of Immunohematology (ICMR), KE Hospital, Mumbai, India.

The Southeast Asian Journal of Tropical Medicine and Public Health
|March 6, 2007
PubMed
Summary

A Punjab student survey revealed high red cell volume, suggesting potential vitamin B12 or folic acid deficiency. Further dietary and supplementation studies explored these findings in beta-thalassemia carriers.

Related Experiment Videos

Last Updated: Jul 16, 2026

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
05:35

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

Area of Science:

  • Hematology
  • Nutritional Science
  • Public Health

Background:

  • Beta-thalassemia carrier screening in Punjab, India, identified an unexpectedly high prevalence of elevated red cell volume (macrocytosis).
  • This macrocytosis was observed more frequently in female students compared to males.
  • Comparative surveys in other Indian states indicated a lower incidence of macrocytosis.

Purpose of the Study:

  • To investigate the cause of elevated red cell volume in students screened for beta-thalassemia.
  • To explore the potential role of vitamin B12 and/or folic acid deficiency in this observation.
  • To assess the impact of dietary modification and vitamin B12 supplementation on red cell volume.

Main Methods:

  • A survey for beta-thalassemia carrier status was conducted among students in Punjab.
  • Students with elevated red cell volume (>99 fL) underwent follow-up assessments.
  • Participants modified their diet and received oral vitamin B12 supplementation over six months.

Main Results:

  • A significant number of students, particularly females, exhibited macrocytosis.
  • Dietary changes and vitamin B12 supplementation were implemented in a subset of affected students.
  • Changes in red cell volume following interventions were monitored and reported.

Conclusions:

  • The findings suggest a probable link between macrocytosis and vitamin B12 or folic acid deficiency in the studied student population.
  • Public health strategies may need to consider nutritional status alongside genetic screening for conditions like beta-thalassemia.
  • Further research is warranted to confirm the etiological factors and optimize interventions.