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Updated: Jul 16, 2026

Visualizing Adhesion Formation in Cells by Means of Advanced Spinning Disk-Total Internal Reflection Fluorescence Microscopy
Published on: January 21, 2019
[The relationship between intracellular actin distribution and morphology and cell adherence]
Chao Cheng1, Jun Zhang, Jiujin Zhu
1Key Lab of Biomechanics and Tissue Engineering under Ministry Education, College of Biology Engineering, Chongqing University, Chongqing 400044, China. cheng2000chao@sohu.com
Abstract:
It is believed that there exists some relationship between the distribution and morphology of intracellular actin and cell adherence. Cells are likely to be deteched when the quantity of actin filament decreases. Actin filaments locate in the fringe of cancer cells and cells cultured in static state, so that these filaments can stretch out and form pseudopodia to adhere to the matrix. When these cells are stimulated their pseudopodia retract so that they can easily be detached from the matrix. When external forces are exerted on cells to adhere and deadhere from the matrix, the morphology and distribution of skeleton actin will change, so as the cells' morphology. The skeleton actins in cells are changed differently to adapt to different external forces which are imposed on the cells. It is obvious that the relationship between the mechanism of cell adhering to the matrix and the morphology & distribution of actins needs more attention.
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