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Elastin in adenomatoid tumor. Light microscopic and electron microscopic study.
Y Nakamura1, A Tanimura, Y Itoh
1Department of Pathology, St. Mary's Hospital, Kurume, Japan.
Archives of Pathology & Laboratory Medicine
|February 1, 1992
Summary
Adenoid tumors in the human genital tract show variable elastin distribution. Elastin presence or absence in the stroma may depend on activated mesothelial cells and fibroblasts.
Area of Science:
- Pathology
- Histology
- Tumor Biology
Background:
- Adenoid tumors are benign neoplasms of the female reproductive tract.
- The stromal composition of adenoid tumors, particularly elastin content, is not well understood.
Purpose of the Study:
- To investigate the distribution and origin of elastin in adenoid tumors of the human genital tract.
Main Methods:
- Histological examination of adenoid tumors.
- Electron microscopy with tannic acid staining.
- Immunohistochemical analysis for elastin.
Main Results:
- Two distinct patterns of stromal elastin distribution were observed: strongly positive or completely negative.
- Elastin was mainly amorphous material with microfibrils, surrounded by collagen and sparse fibroblasts.
- Tumor cells exhibited mesothelial-like features, and elastin appeared to be produced by these cells and stromal fibroblasts.
Conclusions:
- Stromal elastin content in adenoid tumors is highly variable.
- Both activated mesothelial tumor cells and stromal fibroblasts may contribute to elastogenesis in these tumors.