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Benign glandular schwannoma.

J J Brooks¹, R M Draffen

¹Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia.

Archives of Pathology & Laboratory Medicine

|February 1, 1992

Summary

This study reports an extremely rare benign glandular schwannoma, a nerve sheath neoplasm. It highlights the existence of benign variants and their distinct pathological features.

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Area of Science:

Pathology
Oncology
Dermatology

Background:

Glandular schwannomas are rare nerve sheath neoplasms, with most reported cases being malignant.
Divergent differentiation in nerve sheath tumors is uncommon.

Observation:

A case of a benign glandular schwannoma, less than 1 cm, in a 36-year-old woman is described.
The lesion featured a central cystic component lined by cuboidal to low columnar cells with a basement membrane.

Findings:

This represents one of the few reported benign glandular schwannomas.
The tumor's origin is not from dermal adnexal glands.
It can be differentiated from pseudoglandular schwannomas.
Evidence suggests a direct metaplastic origin from the schwannian component.

Implications:

Establishes the existence of a benign glandular schwannoma, crucial for accurate diagnosis.
Pathologists must be aware of this benign entity to avoid misdiagnosis.
Supports the understanding of metaplasia in nerve sheath tumor development.

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