Idiopathic multifocal calcification of the ovarian stroma

We report an apparently unique case of extensive, bilateral, multifocal calcification of the ovarian stroma. The lesion was an incidental finding in a 50-year-old gravida 5, para 5 woman who underwent a hysterectomy and a bilateral salpingo-oophorectomy. Gross inspection revealed ovaries that were of normal size but stony hard. On microscopic examination, the ovarian stroma was extensively replaced by uniformly distributed, spherical foci of calcification that were focally psammomatous. No underlying cause for the calcification, which probably represents an unusual form of dystrophic calcification, could be identified. The differential diagnosis of ovarian calcification, which may arise in diverse conditions, is discussed.