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Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Surgical and interventional visceral revascularization for the treatment of chronic mesenteric ischemia--when to
Matthias Biebl1, W Andrew Oldenburg, Ricardo Paz-Fumagalli
1Section of Vascular Surgery, Department of Surgery, Mayo Clinic, Jacksonville, Florida 32224, USA.
Insights
Surgical revascularization offers better long-term results for chronic mesenteric ischemia (CMI) but has higher initial risks. Endovascular treatment is less invasive, making it suitable for specific patient groups.
Area of Science:
- Vascular Surgery
- Interventional Radiology
Background:
- Chronic mesenteric ischemia (CMI) management requires effective revascularization strategies.
- Comparing surgical and endovascular approaches is crucial for optimizing patient outcomes.
Purpose of the Study:
- To compare the efficacy and safety of surgical revascularization versus endovascular treatment for CMI.
- To evaluate symptom relief, patency rates, morbidity, and mortality between the two treatment modalities.
Main Methods:
- A comparative study involving 49 patients with CMI, divided into surgical (SG) and endovascular (EG) groups.
- Primary endpoint: symptom relief. Secondary endpoints: patency, morbidity, and mortality.
- Statistical significance was set at P < 0.05.
Main Results:
- Surgical revascularization demonstrated superior long-term patency (89% vs. 75%) and fewer reinterventions (0% vs. 13%) compared to endovascular treatment.
- Endovascular repair showed lower early morbidity (4% vs. 42%) and shorter hospital stays (1.3 vs. 11.6 days).
- While not statistically significant (P=0.08), overall mortality was higher in the surgical group (31% vs. 4%).
Conclusions:
- Surgical treatment provides better long-term patency and reduces the need for reintervention in CMI.
- Endovascular treatment is associated with lower immediate risks and may be preferred for patients with comorbidities or unclear symptoms.
- The choice between surgical and endovascular revascularization should be individualized based on patient factors and disease characteristics.
Background:
The purpose of the present study was to compare surgical and endovascular revascularization for chronic mesenteric ischemia (CMI).
Methods:
Forty-nine patients underwent surgical (SG) or endovascular (EG) treatment. Relief of symptoms was considered the primary endpoint; patency, morbidity, and mortality were secondary endpoints. For statistical analysis, significance was assumed if P values < or = 0.05.
Results:
Twenty-six patients (53%) underwent surgical revascularization; 23 patients (47%), endovascular repair. Mean follow-up was 25 +/- 21 months (SG) versus 10 +/- 10 (EG) months (P = 0.07). Except for body mass indices (SG 18.9 +/- 2.7 versus EG 23.6 +/- 4.8; P = 0.001), preoperative data were comparable. Freedom from symptoms was 100% (SG) versus 90% (EG) after intervention (P = 0.194), and 89% (SG) versus 75% (EG) at the end of follow-up. Reocclusion or re-stenosis occurred in 8% (SG) versus 25% (EG) (log-rank test: P = 0.003), and mesenteric ischemia developed in 0% (SG) versus 9% (EG) (P = 0.04). Reintervention for CMI was required in 0% (SG) versus 13% (EG) (P = 0.01). Surgical patients experienced more early complications (42% versus EG 4%; P = 0.02) and longer hospital stays (11.6 +/- 10.9 days versus EG 1.3 +/- 0.5 days; P < 0.001). Overall mortality at the end of follow-up was 31% (SG) versus 4% (EG) (log-rank test: P = 0.08), including all patients with combined open mesenteric and aortic reconstruction (P = 0.001).
Conclusions:
Surgical treatment has superior long-term patency and requires fewer reinterventions, but it is also more invasive with greater morbidity and mortality compared to endovascular treatment. Endovascular techniques may be preferable in patients with significant co-morbidities, concomitant aortic disease, or indeterminate symptoms.
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