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Effect of sodium bicarbonate on canine left ventricular function.

A Bello, J A Bianco, H Velarde

    Angiology
    |June 1, 1977
    PubMed
    Summary

    Sodium bicarbonate administration caused temporary left ventricular depression in dogs, indicated by reduced cardiac function. This effect may stem from increased blood CO2 or hyperosmolality, with potential clinical implications.

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    Area of Science:

    • Cardiology
    • Physiology

    Background:

    • Left ventricular function is crucial for cardiac output.
    • Understanding the effects of intravenous solutions on cardiac performance is vital for patient safety.

    Purpose of the Study:

    • To evaluate the impact of sodium bicarbonate on left ventricular performance in a canine model.
    • To investigate the potential mechanisms behind observed cardiac effects.

    Main Methods:

    • Seven canine subjects underwent right heart bypass preparation.
    • Intraauricular administration of sodium bicarbonate (100 ml, 1100 Osm, 60 mEq) was performed.
    • Left ventricular performance was monitored via pressure and dp/dt measurements.

    Main Results:

    • Sodium bicarbonate induced a mild and transient depression of left ventricular function.

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  • This depression was characterized by decreased left ventricular dp/dt and increased end-diastolic and atrial pressures.
  • Aortic impedance decreased concurrently with left ventricular depression.

    • Conclusions:

    • Sudden increases in blood pCO2 or hyperosmolality may contribute to cardiac depression after sodium bicarbonate administration.
    • The findings suggest potential clinical implications for managing patients receiving sodium bicarbonate infusions.