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Updated: Jul 16, 2026

Production and Targeting of Monovalent Quantum Dots
Published on: October 23, 2014
Identification of quantum dot bioconjugates and cellular protein co-localization by hybrid gel blotting
1Department of Biomedical Engineering, Oregon Health & Science University, 3303 SW Bond Avenue, 13B, Portland, Oregon 97239, USA.
Abstract:
New approaches are needed to address the interaction of nanoparticles and cellular proteins at the molecular level. We present a modification of PAGE co-immunoprecipitation, QD-based PA-AGE electrophoresis blotting, and apply this to identify quantum dot (QD) bioconjugate-cellular protein association. This method provides the capability to isolate and evaluate the action of QD bioconjugate-protein complexes in intact cells and to correlate these identified interactions with their location in cells.
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