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Updated: Jul 16, 2026

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
Published on: July 19, 2024
Treatment of fibrosis in nonalcoholic fatty liver disease
Maarouf A Hoteit1, Frank A Anania
1Division of Digestive Diseases, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Room 248, Atlanta, GA 30322, USA.
Abstract:
Nonalcoholic steatohepatitis (NASH) is one of the most common liver disorders in North America. The mechanism of liver injury in NASH involves insulin resistance and oxidative stress as well as cytokine release. Therapeutic interventions aimed at enhancing insulin sensitivity or reducing oxidative stress have been studied. The role of peptide hormones secreted by adipose tissue--adipocytokines--in the potential pathogenesis of NASH is an area of intense research. As the function of adipokines in modulating hepatic inflammation and fibrosis is elucidated, the potential for novel treatment strategies in patients with NASH is likely to be realized.
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