[Osteoporosis as a first manifestation of systemic mastocytosis. Study of 6 cases]
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Meritxell Sallés1, Susana Holgado, José-Tomás Navarro
1Servicio de Reumatología, CAP Bages, Centre Hospitalari, Manresa, Barcelona, España. 35814ms@lcomb.es
Background And Objective:
We describe 6 cases of secondary osteoporosis due to systemic mastocytosis diagnosed in the last 6 years.
Results:
Three females and 3 males, age range: 47-66 years, diagnosed with osteoporosis were subsequently diagnosed with systemic mastocytosis. Diagnosis delay: 0.5-17 years. Cutaneous involvement was present in 3 patients, hematologic involvement in 2 patients and gastrointestinal involvement in 2 patients. Histamine levels in urine were elevated in all cases. Four patients had fractures. Treatment with bisphosphonates was started. After 3 years the values of bone mineral density (BMD) improved in the 5 patients evaluated. Two patients had new vertebral fractures and started teriparatide.
Conclusions:
Osteoporosis is an unfrequent initial manifestation of systemic mastocytosis. These patients have a high risk of fractures. Our results suggest that although bisphosphonates improve the bone mineral density the risk of fractures persists.
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