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Published on: October 18, 2024
Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and
Erdal Budak1, Nicolas Garrido, Sergio Reis Soares
1Instituto Valenciano de Infertilidad, University of Valencia, Valencia, Spain.
Fertility and Sterility
|March 6, 2007
Summary
This 10-year study shows significant improvements in oocyte donation outcomes, including higher pregnancy rates. Cumulative pregnancy rates remained consistent across different recipient factors, highlighting the effectiveness of oocyte donation treatments.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization
- Oocyte Donation
Background:
- Oocyte donation is a key assisted reproductive technology (ART) for infertility.
- Evaluating long-term outcomes in oocyte donation is crucial for treatment optimization.
Purpose of the Study:
- To compare outcome parameters and cumulative pregnancy rates (PRs) in oocyte donation cycles over a 10-year period.
- To assess the impact of recipient age, indication, and sperm origin on oocyte donation success.
Main Methods:
- Retrospective analysis of 10,537 oocyte donation cycles from 1995-2005.
- Ovarian stimulation and oocyte retrieval in donors; embryo transfer in recipients.
- Outcome parameters and cumulative PRs analyzed based on indication, age, and sperm origin.
Main Results:
- Significant improvements in implantation rate (16.7% to 38.3%) and ongoing PR (31% to 44.3%) were observed.
- Mean embryos transferred decreased from 3.6 to 1.9, enhancing safety.
- Cumulative PRs after 3 and 5 cycles reached 87% and 96.8%, respectively, with no significant differences based on recipient factors.
Conclusions:
- Oocyte donation outcomes have significantly improved over the past decade.
- Cumulative pregnancy rates are consistently high and not significantly affected by recipient age, indication, or sperm origin.
