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Effect of Mitragyna speciosa aqueous extract on ethanol withdrawal symptoms in mice

Ekkasit Kumarnsit1, Niwat Keawpradub, Watcharin Nuankaew

  • 1Department of Physiology, Faculty of Science, Prince of Songkla University (PSU) Hat-Yai, Songkhla 90112, Thailand. ekumarnsit@yahoo.com

Fitoterapia
|March 6, 2007
PubMed

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...