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Related Experiment Videos

[Lactococcus lactis: an opportunistic bacterium?].

A Mofredj1, H Bahloul, C Chanut

  • 1Service de Réanimation, Centre Hospitalier Général de Salon-de-Provence, 207, avenue Julien-Fabre, BP 321, 13658 Salon-de-Provence cedex, France. ali.mofredj@voila.fr

Medecine Et Maladies Infectieuses
|March 6, 2007
PubMed
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Lactic bacteria, used for food preservation and potential biotherapeutics, can rarely cause severe infections in immunocompromised individuals. Despite rare adverse events, their industrial and medical applications remain promising.

Area of Science:

  • Food Science
  • Microbiology
  • Biotechnology

Background:

  • Lactic bacteria have a long history of safe use in food fermentation and preservation.
  • Advancements in cellular biology are exploring lactic bacteria as biotherapeutic agents.
  • These bacteria can produce various proteins, including enzymes, hormones, and immune-stimulating molecules.

Purpose of the Study:

  • To review the potential of lactic bacteria as biotherapeutic agents.
  • To address recent reports of rare human infections associated with lactic bacteria.
  • To assess the implications of these findings for the industrial and medical use of lactic bacteria.

Main Methods:

  • Literature review of historical use and recent case reports.
  • Analysis of the biological properties of lactic bacteria relevant to therapeutic applications.

Related Experiment Videos

  • Evaluation of the risk-benefit profile for industrial and medical applications.
  • Main Results:

    • Lactic bacteria are recognized for their beneficial roles in food and potential therapeutic applications.
    • Rare cases of severe infections have been reported, primarily in patients with comorbidities and linked to unpasteurized dairy consumption.
    • The reported infections, though severe, were infrequent and had favorable outcomes.

    Conclusions:

    • The industrial and medical applications of lactic bacteria should continue, supported by their established safety profile.
    • Ongoing research and development in biotherapeutics utilizing lactic bacteria are warranted.
    • Vigilance regarding potential risks, especially in vulnerable populations, is important.