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Schistosomiasis and pregnancy.

Jennifer F Friedman1, Priya Mital, Hemal K Kanzaria

  • 1Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA. jennifer_friedman@brown.edu

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Summary

Schistosomiasis infection in pregnant women may negatively impact maternal and infant health. More research is needed to understand these effects and the safety of praziquantel treatment during pregnancy.

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Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

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Area of Science:

  • Neglected tropical diseases
  • Maternal and child health
  • Parasitology

Background:

  • Schistosomiasis affects millions of women of childbearing age globally.
  • Limited data exists on schistosome-associated morbidity in pregnant women and their offspring.
  • Animal models suggest adverse effects of schistosome infection on pregnancy outcomes.

Purpose of the Study:

  • To highlight the critical need for research on schistosome infection's impact on pregnancy.
  • To emphasize the importance of well-designed studies for improving birth outcomes in endemic regions.
  • To address the safety of praziquantel treatment in pregnant women.

Main Methods:

  • Review of existing literature, including case reports and observational studies.
  • Analysis of animal model data on schistosome infection and pregnancy.
  • Identification of research gaps in maternal schistosome infection and treatment.

Main Results:

  • Maternal schistosome infection is associated with poor birth outcomes.
  • Evidence suggests a link between maternal infection and decreased birth weight.
  • Data on fetal and neonatal outcomes remains scarce.

Conclusions:

  • Further rigorous research is essential to quantify the impact of schistosomiasis on pregnancy.
  • Investigating praziquantel's safety in pregnancy is crucial for treatment guidelines.
  • Improving birth outcomes in schistosomiasis-endemic areas requires targeted interventions and research.