Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dose calculation using megavoltage cone-beam CT.

Olivier Morin1, Josephine Chen, Michèle Aubin

  • 1Comprehensive Cancer Center, Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA. Morin@radonc17.ucsf.edu

International Journal of Radiation Oncology, Biology, Physics
|March 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of an acute abdominal pain diagnostic pathway in the emergency department.

BMJ open quality·2025
Same author

Management Algorithm for Atypical Lipomatous Tumours: A Retrospective Case Series.

Cureus·2025
Same author

Real-World Use of Electronic Patient-Reported Outcome (ePRO) Tools Integrated in the Electronic Medical Record During Radiation Therapy for Head and Neck Cancer: Feasibility Study.

The Permanente journal·2023
Same author

Evaluation of an emergency safe supply drugs and managed alcohol program in COVID-19 isolation hotel shelters for people experiencing homelessness.

Drug and alcohol dependence·2022
Same author

Primary cutaneous phalangeal neuroendocrine/squamous cell carcinoma with mixed axillary metastasis.

BMJ case reports·2022
Same author

Correction to: Patterns of prevalence and contemporary clinical management strategies in complicated acute biliary calculous disease: an ESTES 'snapshot audit' of practice.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2021

Megavoltage cone-beam CT (MVCBCT) allows accurate dose calculations for head-and-neck cancer patients, effectively tracking anatomical changes and minimizing dosimetric errors with a novel correction method.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Image-Guided Therapy

Background:

  • Anatomical changes during head-and-neck cancer treatment can significantly impact radiation dose delivery.
  • Megavoltage cone-beam CT (MVCBCT) offers in-room imaging capabilities but is susceptible to artifacts like cupping.
  • Accurate dose calculation on MVCBCT is crucial for adapting treatment plans to patient anatomy.

Purpose of the Study:

  • To assess the feasibility of dose calculation using MVCBCT in head-and-neck patients.
  • To quantify dosimetric errors arising from anatomical variations during treatment.
  • To validate a method for correcting MVCBCT artifacts for improved accuracy.

Main Methods:

  • Developed a geometric model to correct MVCBCT cupping artifacts using a water phantom.

Related Experiment Videos

  • Calibrated uniformity-corrected MVCBCT for physical density.
  • Recalculated dose distributions using treatment plan parameters on MVCBCT images.
  • Validated the approach with phantom studies and clinical cases, including patients with significant weight loss.

    • Main Results:

    • A head-size water phantom's nonuniformity caused <5% dosimetric error.
    • The uniformity correction reduced cupping artifacts, leading to <1% dosimetric inaccuracies.
    • Clinical validation showed agreement within 3% and 3 mm between MVCBCT and CT dose calculations.
    • Dose-volume histograms demonstrated excellent agreement between the two imaging modalities.

    Conclusions:

    • MVCBCT is a feasible tool for dose calculation in head-and-neck cancer patients.
    • The developed correction method significantly improves accuracy.
    • MVCBCT can reliably estimate the dosimetric impact of anatomical changes on critical structures.