Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers.

Environmental health : a global access science source·2018
Same author

Clinical characteristics of chronic lymphocytic leukemia occurring in chornobyl cleanup workers.

Hematological oncology·2016
Same author

The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: III. Radiation risks.

Radiation research·2009
Same author

Myelodysplasia and radiation.

Radiation research·2004
Same author

Histologic verification of leukemia, myelodysplasia, and multiple myeloma diagnoses in patients in Ukraine, 1987-1998.

International journal of hematology·2002

Related Experiment Video

Updated: Jul 16, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Radiation-induced leukemia: lessons from history.

Stuart C Finch1

  • 1University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, USA. finch@umdnj.edu

Best Practice & Research. Clinical Haematology
|March 6, 2007
PubMed
Summary

The discovery of ionizing radiation in 1895 led to early confusion about its health effects, but later research confirmed radiation can induce leukemia. Studies on Hiroshima and Nagasaki survivors advanced understanding of radiation-induced leukemia.

More Related Videos

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments
06:08

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Published on: May 26, 2019

Related Experiment Videos

Last Updated: Jul 16, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments
06:08

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Published on: May 26, 2019

Area of Science:

  • Medical History
  • Radiation Oncology
  • Hematology

Background:

  • The discovery of ionizing radiation sources like x-rays, radium, and polonium began in 1895.
  • Early research on radiation effects was marked by confusion and a failure to link exposure to leukemia induction.

Observation:

  • The initial 50 years post-discovery saw limited understanding of radiation's carcinogenic potential.
  • The subsequent 60 years brought acceptance of radiation's role in leukemia development.

Findings:

  • Significant progress has been made in characterizing the clinical and pathophysiological aspects of radiation-induced leukemia.
  • Studies on atomic bomb survivors in Hiroshima and Nagasaki provide critical insights into radiation exposure effects.

Implications:

  • Understanding radiation-induced cell damage is crucial for developing preventative and therapeutic strategies.
  • Ongoing research continues to address unanswered questions regarding the long-term consequences of radiation exposure.