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Worldwide mortality from cirrhosis: an update to 2002
Cristina Bosetti1, Fabio Levi, Franca Lucchini
1Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy. bosetti@marionegri.it
Journal of Hepatology
|March 6, 2007
Summary
Global cirrhosis mortality has declined significantly due to reduced alcohol and viral hepatitis. However, rising trends persist in the UK and Eastern Europe, linked to increased alcohol consumption.
Area of Science:
- Epidemiology
- Public Health
- Hepatology
Background:
- Cirrhosis mortality rates have undergone substantial global shifts in recent decades.
- Understanding these trends is crucial for public health interventions.
Purpose of the Study:
- To analyze global trends in cirrhosis mortality from 1980 to 2002.
- To identify regional variations and contributing factors to mortality changes.
Main Methods:
- Utilized age-standardized cirrhosis mortality rates per 100,000 population.
- Data sourced from the World Health Organization (WHO) mortality database for 41 countries.
- Analysis covered the period from 1980 to 2002.
Main Results:
- Most countries worldwide experienced a steady decline in cirrhosis mortality since the mid-late 1970s.
- Southern European countries saw rates decrease by over 50% by the early 2000s.
- Conversely, Eastern European nations showed rising rates peaking in the mid-1990s, with recent declines. The UK exhibited consistent increases in mortality rates for both sexes.
Conclusions:
- Favorable global trends in cirrhosis mortality are linked to reduced alcohol consumption and hepatitis B and C virus infections.
- Persistent increases in alcohol consumption contribute to rising cirrhosis mortality in the UK and parts of Eastern Europe.
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