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Serum protein profile of rheumatoid arthritis treated with anti-TNF therapy (infliximab)

Tohru Takeuchi1, Toyofumi Nakanishi, Yoko Tabushi

  • 1First Department of Internal Medicine, Osaka Medical College, Daigaku-Machi 2-7, Takatsuki, Osaka 569-8686, Japan. t-takeuchi@poh.osaka-med.ac.jp

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
|March 6, 2007
PubMed

We analyzed the changes in the serum protein profile by infliximab using two-dimensional gel electrophoresis and mass spectrometry. More than 50 gel spots were seen to increase or decrease in correlation with clinical improvements of RA. The spots corresponding to CRP, C3, and Apo J showed reduced staining intensity, while the spots corresponding to Apo A-I, RBP, and transthyretin were enhanced. The protein profile of RA patients treated with infliximab was mostly similar to that of normal healthy controls except for several protein spots. This suggested that infliximab normalized the serum protein profile of RA patients, leading to modification in the serum lipid profile and antioxidant status in RA.

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