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Updated: Jul 16, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
What endocrinologists should know about growth hormone measurements
Martin Bidlingmaier1, Christian J Strasburger
1Endocrine Research Laboratories, Medizinische Klinik-Innenstadt, Ludwig-Maximilians University, Ziemssenstrasse 1, Munich 80336, Germany. martin.bidlingmaier@med.uni-muenchen.de
Abstract:
Determination of human growth hormone (GH) concentration in serum plays a key role in the diagnosis of GH deficiency and GH excess (acromegaly). Methods of measuring GH still lack standardization and show considerable between-method variability. Therefore, correct interpretation of GH test results requires knowledge of measurement techniques and awareness of potential problems in applying recommendations for cut-off values given in the literature. This article focuses on the molecular, structural, and methodologic background of the heterogeneity of assay results and on possible next steps toward standardization.
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