Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissociable structural and molecular pathways of age-related change in sustained attention.

bioRxiv : the preprint server for biology·2026
Same author

Metal- and Redox-Dependent Oxytocin Species Differentially Regulate Invasion and Migration in Triple-Negative Breast Cancer.

ACS chemical biology·2026
Same author

Pediatric phlyctenular keratoconjunctivitis and its spectrum of disease: An updated review.

The ocular surface·2026
Same author

Metal Modulation of Oxytocin Structure, Function, and Receptor Interactions.

European journal of inorganic chemistry·2026
Same author

Anastomotic leakage increases the risk of major low anterior resection syndrome 3 years after rectal cancer surgery.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same author

Safety and Feasibility of Algorithmic Continuous Glucose Monitoring-Based Titration in People with Type 2 Diabetes Using Insulin Degludec, With or Without Noninsulin Glucose-Lowering Drugs: A 16-Week Randomized Controlled Trial.

Diabetes technology & therapeutics·2026

Related Experiment Video

Updated: Jul 16, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Growth hormone supplementation in the elderly.

Ralf Nass1, Jennifer Park, Michael O Thorner

  • 1Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia, 450 Ray C. Hunt Drive, Charlottesville, VA 22903, USA.

Endocrinology and Metabolism Clinics of North America
|March 6, 2007
PubMed
Summary

Aging adults face health challenges. Growth hormone (GH) therapies may improve body composition and function in the elderly, but more research is needed to ensure safety and efficacy.

More Related Videos

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Related Experiment Videos

Last Updated: Jul 16, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Area of Science:

  • Gerontology
  • Endocrinology
  • Metabolic Medicine

Background:

  • The global population is rapidly aging, presenting significant societal and healthcare challenges.
  • Maintaining independence and preventing frailty, chronic diseases, and disabilities in older adults is a key imperative.
  • Aging is associated with hormonal changes, notably a decline in growth hormone (GH), mirroring changes seen in GH deficiency.

Purpose of the Study:

  • To review existing studies on the effects of growth hormone (GH) and GH secretagogues in the elderly.
  • To examine the impact of these therapies on body composition and functional capacity in older adults.
  • To discuss safety considerations and the necessity for further controlled research in this demographic.

Main Methods:

  • Literature review of studies investigating GH and GH secretagogues in elderly populations.
  • Analysis of data concerning changes in body composition and functional parameters.
  • Evaluation of reported safety profiles and identified research gaps.

Main Results:

  • Studies indicate that GH and GH secretagogues can influence body composition in aging individuals.
  • Observed changes in body composition during aging are similar to those in GH-deficient adults.
  • Data on functional improvements and long-term safety in the elderly require further investigation.

Conclusions:

  • Hormonal changes, particularly GH decline, play a role in aging-related body composition alterations.
  • GH-based therapies show potential for improving geriatric health, but require cautious application.
  • Further rigorous, controlled clinical trials are essential to establish the efficacy and safety of these interventions in the elderly.