Related Experiment Video
Updated: Jul 16, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Myoclonus and extrapyramidal diseases
1Department of Neurology and Movement Disorders, EA2683, IFR114, Lille University Medical Centre, Hôpital Roger-Salengro, 59037 Lille cedex, France. ldefebvre@chru-lille.fr
Abstract:
Parkinsonism or dystonia are associated with myoclonus in several extrapyramidal diseases. Although the latter symptom is not always prominent, stimulus-sensitive, distal, or focal reflex myoclonus is frequently observed. This review will consider the clinical and electrophysiological features of myoclonus in Parkinson's disease, multiple system atrophy, corticobasal degeneration, progressive supranuclear palsy, Huntington's disease, dentatorubral-pallidoluysian atrophy, Lewy body dementia, and myoclonus with dystonia. The evidence of a long-latency reflex response, the presence of giant somatosensory evoked potentials, and the demonstration of a back-averaged premyoclonus focal cortical EEG activity often lead to classify myoclonus as a cortical phenomenon. However, a subcortical origin cannot always be ruled out.
Related Concept Videos
Alterations in Muscle Tone lll
Alterations in Muscle Tone ll
Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Parkinson's Disease: Overview
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Parkinson Disease l: Introduction
