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Published on: March 17, 2016
Estrogen receptor beta gene +1730 G/A polymorphism in women with endometriosis
Gyoung Hoon Lee1, Sung Hoon Kim, Young Min Choi
1Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Objective:
To investigate whether the +1730 G/A polymorphism of the estrogen receptor beta (ER-beta) gene is associated with the risk of endometriosis in a Korean population.
Design:
Case-control study.
Setting:
University Department of Obstetrics and Gynecology.
Patient(S):
Women with (n = 239) or without (n = 287) endometriosis.
Intervention(S):
The +1730 G/A polymorphism of 3'-UTR of exon 8 in the ER-beta gene was assessed by polymerase chain reaction-restriction fragment-length polymorphism analysis utilizing digestion with AluI restriction enzyme.
Main Outcome Measure(S):
Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene.
Results:
The genotype distribution of the +1730 G/A polymorphism in the ER-beta gene was not different between the endometriosis patients and the controls (G/G of 74.9% vs. 72.5%, G/A of 25.1% vs. 26.1%, and A/A of 0.0% vs. 1.4%, respectively). There was also no difference in the G and A allele frequencies between the two groups (87.4% vs. 85.5%, and 12.6% vs. 14.5%, respectively). Even when the endometriosis cases were subdivided into American Society for Reproductive Medicine stage I-II, III, IV, and III-IV, no differences were found at all in the genotype distribution or allele frequencies between the two groups.
Conclusion(S):
Our results suggest that the +1730 G/A polymorphism of the ER-beta gene may not be associated with the risk of endometriosis in the Korean population, which was not the case in the Japanese population.
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