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Related Experiment Videos

An immunomodulating pectic polymer from Glinus oppositifolius.

Kari T Inngjerdingen1, Hiroaki Kiyohara, Tsukasa Matsumoto

  • 1Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N-0316 Oslo, Norway. k.t.inngjerdingen@farmasi.uio.no <k.t.inngjerdingen@farmasi.uio.no>

Phytochemistry
|March 6, 2007
PubMed
Summary
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The immunomodulating polymer GOA1 from Glinus oppositifolius has a complex structure involving galactans and arabinans. Its bioactivity, including complement fixation, is linked to specific structural elements like arabinofuranosyl residues.

Area of Science:

  • Plant biochemistry
  • Immunology
  • Medicinal plant research

Background:

  • Glinus oppositifolius (Aizoaceae) yields an immunomodulating pectic polymer, GOA1.
  • Previous studies suggested GOA1 comprises arabinogalactans and a rhamnogalacturonan backbone.

Purpose of the Study:

  • To elucidate the detailed structure of the pectic polymer GOA1.
  • To investigate the structure-activity relationships of GOA1's immunomodulatory functions.

Main Methods:

  • Enzymatic degradation using five specific glycosidases.
  • Weak acid hydrolysis.
  • Assessment of complement fixing and intestinal immune stimulating activities.

Main Results:

  • GOA1 contains galactopyranosyl (Galp) main chains with arabinofuranosyl (Araf) side chains and a galactopyranosyl backbone.

Related Experiment Videos

  • GOA1 induces B cell proliferation, IL-1beta secretion by macrophages, and IFN-gamma mRNA in NK cells.
  • Enzymatic degradation preserving Araf residues did not alter bioactivity; acid hydrolysis reduced complement fixing activity.

    • Conclusions:

    • The structure of GOA1 involves specific linkages of galactans and arabinans.
    • Reduced bioactivity after acid hydrolysis is attributed to loss of Araf units, altered Galp linkages, and decreased molecular weight.