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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Might there be a link between mannose binding lectin and vitiligo?

Huseyin Onay¹, Mustafa Pehlivan, Sibel Alper

¹Department of Medical Genetics, Faculty of Medicine, Ege Universitesi, 35100 Bornova Izmir, Turkey. huseyin.onay@ege.edu.tr

European Journal of Dermatology : EJD

|March 6, 2007

Summary

Mannose-binding lectin (MBL) gene variants are linked to vitiligo susceptibility. Specifically, MBL2 codon 54 polymorphisms (alleles AB and BB) were significantly more frequent in vitiligo patients, suggesting a role in disease development.

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Direct Reprogramming of Mouse Fibroblasts into Melanocytes

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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

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Published on: August 27, 2021

Area of Science:

Immunogenetics
Dermatology
Molecular Biology

Background:

Mannose-binding lectin (MBL) is a calcium-dependent lectin.
MBL plays a role in innate immunity and is associated with infections and autoimmune diseases.
Vitiligo is an autoimmune condition affecting skin pigmentation.

Purpose of the Study:

To investigate the association between MBL2 gene variants and vitiligo.
To analyze specific polymorphisms in the MBL2 gene, namely codon 54 (allele B) and codon 57 (allele C).

Main Methods:

Genotyping of MBL2 gene polymorphisms using the PCR-RFLP method.
Analysis of samples from 40 vitiligo patients and 50 healthy controls.
Comparison of allele and genotype frequencies between patient and control groups.

Main Results:

Codon 57 polymorphism was not detected in any participants.
Significantly higher frequencies of low-level MBL2 genotypes (codon 54: AB and BB) were observed in vitiligo patients (37.5%) compared to controls (6%) (p < 0.001).
The B allele frequency at codon 54 was significantly higher in patients (20%) versus controls (3%).

Conclusions:

MBL2 codon 54 polymorphism is associated with an increased susceptibility to vitiligo.
These findings suggest a potential role for MBL2 gene variants in the pathogenesis of vitiligo.