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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Tumor Microenvironment

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Related Experiment Video

Updated: Jul 16, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

CCR7 mediates inflammation-associated tumor progression.

Yvonne K Mburu1, Jun Wang, Michelle A Wood

  • 1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Immunologic Research
|March 6, 2007
PubMed
Summary

Chemokine receptor 7 (CCR7) is upregulated in head and neck cancers, promoting tumor survival and metastasis. NF-kappaB signaling regulates CCR7, driving SCCHN malignancy progression.

Related Experiment Videos

Last Updated: Jul 16, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Chemokine receptor 7 (CCR7) facilitates leukocyte trafficking to lymphoid organs.
  • Aberrant CCR7 expression is implicated in cancer progression, including pro-survival and invasive pathways.
  • Selective CCR7 upregulation is observed in metastatic squamous cell carcinoma of the head and neck (SCCHN).

Purpose of the Study:

  • To review the understanding of CCR7-mediated signaling in metastatic SCCHN.
  • To provide evidence for CCR7's role in tumor survival, invasion, and metastasis.
  • To elucidate the regulatory mechanisms of CCR7 expression and signaling in SCCHN.

Main Methods:

  • Review of existing literature on CCR7 signaling in SCCHN.
  • Analysis of autocrine and paracrine signaling pathways involving CCR7 ligands (CCL19, CCL21).
  • Investigation of NF-kappaB regulation of CCR7 expression and downstream signaling.

Main Results:

  • CCR7 activation by CCL19 and CCL21, expressed by lymphatic endothelium and tumor cells, propagates signaling.
  • NF-kappaB regulates CCR7 expression and sustains the autocrine signaling pathway in SCCHN.
  • Downstream NF-kappaB-mediated CCR7 signals are crucial for SCCHN malignancy progression.

Conclusions:

  • CCR7 plays a significant role in the survival, invasion, and metastasis of SCCHN.
  • The NF-kappaB pathway is a key regulator of CCR7 expression and signaling in SCCHN.
  • Targeting CCR7 or its regulatory pathways may offer therapeutic strategies for SCCHN.