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Updated: Jul 16, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
Gene therapy for type 1 diabetes: is it ready for the clinic?
Antonella D'Anneo1, Pleunie Rood, Rita Bottino
1Diabetes Institute, Children's Hospital of Pittsburgh, Pittsburgh 15213, USA.
Abstract:
This review, in addition to updating the growing list of type 1 diabetes- relevant gene therapies, offers an outline of short-term objectives that can readily be met to move, at least, adenoviral and adeno-associated viral-based protocols into the clinic, first as a means of facilitating islet allografts as well as platforms with which to introduce immunoregulatory transgenes. A wide array of genes have been tested to restore insulin production, to drive the differentiation of insulin-producing progenitors, and to confer immunosuppression in an antigen- and tissue-restricted manner.
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