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A clinico-pathologic correlation
Amir Naimi1, Richard D'Innocenzo
1Tufts University School of Dental Medicine, USA.
Journal of the Massachusetts Dental Society
|March 7, 2007
Summary
Bisphosphonates (BPs), used since the 1960s for bone conditions, can lead to bisphosphonate-related osteonecrosis (BRON) of the jaws. This review covers BP principles, side effects, and management, including clinical cases.
Area of Science:
- Pharmacology
- Oncology
- Dentistry
Background:
- Bisphosphonates (BPs) have been utilized since the late 1960s for bone imaging, metabolic bone diseases, and cancer-related hypercalcemia and osteolysis.
- Despite their efficacy, bisphosphonate therapy carries a potential risk of bisphosphonate-related osteonecrosis (BRON) of the jaws.
Observation:
- Recent publications highlight BRON as a significant sequela of bisphosphonate treatment.
- Healthcare providers, particularly dentists, are increasingly focused on recognizing and managing issues in patients undergoing bisphosphonate therapy.
Findings:
- This article reviews the fundamental principles of bisphosphonate therapy and its associated side effects.
- Management guidelines for BP therapy are summarized.
- The authors present one of eleven cases of BRON managed in their clinic over the past five years.
Implications:
- Understanding bisphosphonate therapy and its potential side effects like BRON is crucial for effective patient management.
- Adherence to management guidelines can help mitigate risks associated with bisphosphonate use.
- Clinical case reports contribute valuable real-world data for refining treatment strategies and improving patient outcomes.
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