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Updated: Jul 16, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
Synthesis of the oxygenated pactamycin core
1Department of Chemistry & Chemical Biology, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA. spencer.knapp@rutgers.edu
Abstract:
[structure: see text]. Pactamycin, one of the most complex and densely functionalized aminocyclitol antibiotics known, presents synthetic challenges that include reactivity and sterics, relative and absolute stereochemistry, and functional group compatibility and protection. An approach is reported that features four different types of (cyclopentane) face selective functionalization reactions and results in a polyfunctionalized and appropriately protected intermediate that incorporates all the core carbons and the oxygenated functionality of the target.
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