Related Experiment Video
Updated: Jul 16, 2026

High-Resolution Complexome Profiling by Cryoslicing BN-MS Analysis
Published on: October 15, 2019
Modeling protein-protein complexes involved in the cytochrome C oxidase copper-delivery pathway
Aalt D J van Dijk1, Simone Ciofi-Baffoni, Lucia Banci
1Bijvoet Center for Biomolecular Research, Science Faculty, Utrecht University, 3584CH, Utrecht, The Netherlands.
Abstract:
Proper assembly and function of cytochrome c oxidase, which catalyzes the reduction of O2 and generates the proton gradient driving ATP synthesis, depend on correct copper delivery and incorporation. Structural details about the protein-protein complexes involved in this process are still missing. We describe here models of four complexes along this pathway obtained by combining bioinformatics interface predictions with information-driven docking and discuss their relevance with respect to known and pathogenic mutations.
More Related Videos
Related Concept Videos
Electron Transport Chain: Complex III and IV
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
The Supercomplexes in the Crista Membrane
Electron Transport Chains
The ETC is comprised of...
Protein Transport to the Thylakoids
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...

