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Related Experiment Video

Updated: Jul 16, 2026

Postoperative Ileus Murine Model

Postoperative Ileus Murine Model

Published on: July 12, 2024

Bowel perforation after single-dose activated charcoal.

Jason P Green¹, William McCauley

¹Department of Emergency Medicine, University of Calgary, Calgary, Alberta, Canada.

|March 7, 2007

Summary

Activated charcoal is used for medication overdose but can cause rare complications. A patient with undiagnosed diverticular disease experienced sigmoid perforation after a single dose, highlighting potential risks.

Area of Science:

Emergency Medicine
Gastroenterology
Toxicology

Background:

Activated charcoal is a common initial treatment for gastrointestinal decontamination in patients with medication overdose.
Complications from activated charcoal administration are infrequent but can be serious.

Observation:

A case report details a patient with previously unrecognized diverticular disease.
This patient developed sigmoid perforation following a single dose of activated charcoal administered for drug overdose.

Findings:

The sigmoid perforation occurred in a patient who received activated charcoal without a cathartic.
A literature review found no prior reports of bowel perforation linked to single-dose activated charcoal.

Implications:

Related Experiment Videos

Last Updated: Jul 16, 2026

Postoperative Ileus Murine Model

Postoperative Ileus Murine Model

Published on: July 12, 2024

This case underscores the potential for severe adverse effects from activated charcoal, even in single doses.
The findings suggest a need to consider patient history, such as undiagnosed diverticular disease, before administering activated charcoal and to evaluate the role of cathartics in preventing complications.