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[Atherosclerosis as a systemic disease].

Carlos Lahoz¹, José M Mostaza

¹Unidad de Arteriosclerosis, Hospital Carlos III, Madrid, Spain. clahoz.hciii@salud.madrid.org

Revista Espanola De Cardiologia

|March 7, 2007

Summary

Atherosclerosis, a progressive arterial disease, causes significant mortality and morbidity globally. Early detection and systemic treatments like statins are crucial for managing this widespread condition.

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Area of Science:

Cardiovascular Science
Vascular Biology
Public Health

Context:

Atherosclerosis is a prevalent, progressive disease affecting medium-sized arteries, leading to ischemic heart disease, cerebrovascular disease, and peripheral arterial disease.
In Spain, it causes 124,000 deaths annually, posing a substantial public health challenge despite declining aged-adjusted cardiovascular mortality rates.

Purpose:

To summarize the nature, risk factors, detection methods, and systemic treatment strategies for atherosclerosis.
To highlight the importance of recognizing atherosclerosis as a systemic disease affecting multiple vascular beds.

Summary:

Atherosclerosis involves medium arteries and presents clinically as various ischemic diseases. Risk factors are universal across affected areas.
Subclinical atherosclerosis can be identified using risk tables, inflammatory markers, imaging, and the ankle-brachial index.
Systemic treatments including statins, antiplatelet agents, and ACE inhibitors are effective regardless of the affected vascular territory.

Impact:

Understanding atherosclerosis as a systemic disease informs comprehensive patient management strategies.
Early identification and intervention can mitigate the significant morbidity and mortality associated with atherosclerosis.
Consistent therapeutic approaches offer broad benefits across different vascular manifestations of the disease.

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