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Urticaria due to calcium pidolate.

J Domínguez-Ortega1, C Abad-Schilling, C Kindelan

  • 1Unit of Allergology, Hospital Universitario de Getafe, Madrid, Spain. jdort@mixmail.com

Allergologia Et Immunopathologia
|March 7, 2007
PubMed
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This study documents the first known case of allergy to calcium-pidolate, a common osteoporosis treatment. The patient experienced a severe skin reaction but tolerated calcium carbonate, indicating specific drug hypersensitivity.

Area of Science:

  • Allergy and Immunology
  • Pharmacology
  • Dermatology

Background:

  • Calcium salts are widely used for osteoporosis prevention and treatment.
  • Adverse reactions to calcium salts typically involve gastrointestinal issues, parathyroid effects, or bone resorption.
  • Calcium-pidolate is one such salt prescribed for bone health.

Observation:

  • A 52-year-old woman developed an itchy, maculopapular rash 90 minutes after her second dose of calcium-pidolate.
  • Skin Prick Tests for calcium-pidolate and calcium carbonate were negative.
  • An oral challenge with calcium-pidolate induced a similar erythematous and itchy papular rash.

Findings:

  • The patient exhibited a clear allergic reaction specifically to calcium-pidolate.
  • Subsequent oral challenge with calcium carbonate demonstrated good tolerance, ruling out a general calcium salt allergy.

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  • This case represents the first documented instance of allergy to calcium-pidolate.

    • Implications:

    • Highlights the potential for specific hypersensitivity reactions to calcium-pidolate, distinct from other calcium salts.
    • Suggests the need for careful consideration of calcium-pidolate in patients with a history of drug allergies or sensitivities.
    • Underscores the importance of diagnostic allergy testing to differentiate reactions to specific calcium compounds.