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Methicillin-resistant Staphylococcus aureus in critical care areas
1Adult Nurse Practitioner Program, Vanderbilt University School of Nursing, 461, 21st Avenue South, 367 Frist Hall, Nashville, TN 37240, USA. travis.dunlap@vanderbilt.edu
Abstract:
In recent years the mainstay of treatment for hospital-associated MRSA infections has been vancomycin, but now vancomycin intermediate S aureus strains are beginning to emerge. Complete vancomycin resistant S aureus can develop, possessing the same vanA gene as vancomycin-resistant enterococcus. Four such isolates have been reported, three of which have been in the United States. There are new antibiotics being developed, but there is always a risk of resistance developing. There are some promising new ideas such as staphylococcal conjugate vaccines that reduce the rates of S aureus bacteremia for up to 10 months postimmunization in patients who have end stage renal disease receiving hemodialysis, but studies are ongoing. With all the uncertainty surrounding treatment, at least one medium has remained consistent and effective if used properly--infection control. But this requires complete support of all healthcare workers and hospital administration from the chief medical officer to doctors and nurses to environmental services personnel to take ownership of an effective infection control program. Who will advocate for more stringent infection control policies and for the equipment to successfully carry them out? Who will take the lead by ensuring implementation of infection control policies on a unit is effective? Who will hold themselves and other health care workers including physicians accountable to comply with these infection control policies every time they enter a patient's room? Nurses are on the front lines in the battle against antibiotic-resistant nosocomial infections such as MRSA, and we should not be apathetic or feel we are helpless. It is our duty as patient advocates not to take a spectator role but to answer these questions: "I will."
Insights
Emerging vancomycin-intermediate Staphylococcus aureus (VISA) and vancomycin-resistant Staphylococcus aureus (VRSA) necessitate robust infection control. Healthcare workers must champion and adhere to stringent infection control policies to combat these antibiotic-resistant bacteria.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Hospital-associated MRSA infections traditionally treated with vancomycin face emerging resistance.
- Vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) strains are appearing, with VRSA carrying the vanA gene.
- The development of antibiotic resistance poses a significant threat to effective treatment strategies.
Purpose of the Study:
- To highlight the growing threat of vancomycin resistance in Staphylococcus aureus.
- To emphasize the critical role of infection control in managing antibiotic-resistant nosocomial infections.
- To advocate for increased accountability and adherence to infection control policies among healthcare professionals.
Main Methods:
- Review of current treatment challenges for MRSA infections.
- Discussion of emerging resistance mechanisms and new therapeutic avenues.
- Analysis of the importance and implementation of infection control protocols.
Main Results:
- Vancomycin, a primary treatment, is becoming less effective due to emerging intermediate and resistant strains.
- New antibiotics and vaccines are under development, but resistance remains a concern.
- Effective infection control remains a consistent and crucial strategy, requiring universal support and adherence.
Conclusions:
- The rise of VISA and VRSA necessitates a renewed focus on infection control measures.
- Healthcare workers, including nurses, have a vital role in advocating for and implementing stringent infection control policies.
- Proactive and consistent adherence to infection control protocols is essential to combat antibiotic resistance in healthcare settings.
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