Related Experiment Video
Updated: Jul 16, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Castleman's disease: A rare lymphoproliferative disorder
T E F Jongsma1, R J Verburg, P H L M Geelhoed-Duijvestijn
1Medisch Centrum Haaglanden, Department of Internal Medicine, The Hague, The Netherlands.
European Journal of Internal Medicine
|March 7, 2007
Summary
Castleman's disease (CD) is a rare lymphoproliferative disorder with localized and multicentric forms. This report details the clinical and pathological spectrum of Castleman's disease, aiding diagnosis and understanding.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Castleman's disease (CD) is a rare, atypical lymphoproliferative disorder.
- First described in 1956, CD has had various historical names including angiofollicular mediastinal lymph node hyperplasia.
- CD is a heterogeneous condition presenting as either localized or systemic (multicentric) disease.
Purpose of the Study:
- To discuss the spectrum of clinical and pathological findings in Castleman's disease.
- To differentiate between localized and multicentric forms of CD.
- To highlight the distinct subtypes of localized Castleman's disease: hyaline-vascular (HV) and plasma cell (PC) types.
Main Methods:
- Review of clinical presentations and pathological features of Castleman's disease.
- Histopathological analysis differentiating between HV and PC types of localized CD.
- Comparison of clinical manifestations between localized and multicentric CD.
Main Results:
- Localized Castleman's disease presents as either the hyaline-vascular (HV) type or the plasma cell (PC) type.
- The HV type typically presents with minimal symptoms and shows abnormal follicles with increased vascularity.
- The PC type and multicentric CD present with more pronounced clinical symptoms, including fever, night sweats, and lymphadenopathy.
Conclusions:
- Castleman's disease encompasses a range of clinical and pathological presentations.
- Accurate differentiation between localized (HV and PC types) and multicentric forms is crucial for patient management.
- Understanding the spectrum of findings aids in the diagnosis and treatment of this rare disorder.
Related Concept Videos
01:27Disorders of Leukocytes
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
01:25Cardiomyopathy I: Introduction and Classification
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
01:30Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...