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Related Experiment Video

Updated: Jul 16, 2026

Quantitative Analysis of Dietary Vitamin A Metabolites in Murine Ocular and Non-Ocular Tissues Using High-Performance Liquid Chromatography
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STRA6, a cell-surface receptor for retinol-binding protein: the plot thickens.

William S Blaner1

  • 1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. wsb2@columbia.edu

Cell Metabolism
|March 7, 2007
PubMed
Summary

Cellular uptake of retinol (vitamin A) is clarified by identifying a retinol-binding protein (RBP) receptor. This discovery advances understanding of retinoid biology and cellular processes.

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Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Published on: January 28, 2013

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Cellular uptake of retinol (vitamin A) has been studied since the 1970s.
  • The cell-surface receptor for retinol-binding protein (RBP) has been a key area of research.
  • Understanding retinoid transport is crucial for various biological processes.

Purpose of the Study:

  • To elucidate the molecular identity and properties of the RBP receptor.
  • To provide new research avenues for understanding retinoid biology.
  • To clarify the mechanism of cellular retinol uptake.

Main Methods:

  • Utilized recent reports by Kawaguchi et al. (2007) and Pasutto et al. (2007).
  • Focused on data regarding the molecular identity and properties of the RBP receptor.
  • Experimental approaches likely involved molecular biology and biochemical assays.

Main Results:

  • Compelling data presented on the molecular identity of the RBP receptor.
  • Key properties of the RBP receptor have been elucidated.
  • New insights into how cells internalize retinol.

Conclusions:

  • The molecular identity of the RBP receptor is now better understood.
  • These findings open new avenues for research into retinoid metabolism and function.
  • Enhanced understanding of cellular vitamin A uptake mechanisms.