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Primary diffuse large B-cell lymphoma of the stomach
Andrés J M Ferreri1, Carlos Montalbán
1Medical Oncology Unit, San Raffaele Scientific Institute, Milan, Italy. andres.ferreri@hsr.it
Critical Reviews in Oncology/Hematology
|March 7, 2007
Summary
Diffuse large B-cell lymphoma (DLBCL) of the stomach, often linked to Helicobacter pylori, shows good prognosis with chemotherapy. Further research is needed to define optimal treatments, including rituximab and antibiotics.
Area of Science:
- Gastroenterology
- Hematology
- Oncology
Background:
- The stomach is a frequent extranodal site for non-Hodgkin lymphomas.
- Diffuse large B-cell lymphoma (DLBCL) is the predominant histotype in the stomach.
- DLBCL can be associated with Helicobacter pylori infection and MALT areas.
Purpose of the Study:
- To review the characteristics and treatment of gastric DLBCL.
- To highlight the current therapeutic strategies and remaining questions in managing this malignancy.
Main Methods:
- Literature review of gastric non-Hodgkin lymphomas, focusing on DLBCL.
- Analysis of histopathological features, epidemiology, and treatment outcomes.
- Discussion of current standard treatments and emerging therapeutic options.
Main Results:
- Gastric DLBCL is aggressive but curable, with a near 90% 5-year survival with adequate therapy.
- Chemotherapy with anthracyclines, potentially followed by radiotherapy, is the standard treatment, replacing gastrectomy.
- The disease predominantly affects males aged 50-60 years.
Conclusions:
- Adequate therapeutic strategies yield good prognoses for gastric DLBCL.
- Unanswered questions remain regarding the optimal role of rituximab, consolidation radiotherapy, and H. pylori-eradicating therapy.
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